Genomic and clinical characterization of early T-cell precursor lymphoblastic lymphoma

Abstract Early T-cell precursor phenotype acute lymphoblastic leukemia (ETP-ALL) is a subtype of T-ALL with unique immunophenotype and genetic abnormalities distinct from conventional T-ALL. A subset T lymphoma (T-LLy) also demonstrates the early may be counterpart ETP-ALL. Unlike ETP-ALL, incidence, clinical features, genomic features ETP-LLy are unknown. We reviewed immunophenotyping data 218 T-LLy patients who enrolled in Children’s Oncology Group AALL0434 trial identified 9 cases (4%) exhibiting definitive ETP immunophenotype. performed single-nucleotide polymorphism array profiling on 15 non-ETP cases. Compared T-LLy, showed less frequent deletion 9p (CKDN2A/B), more 12p (ETV6) 1p (RPL22), absence biallelic receptor γ deletions. Recurrent previously described ETP-ALL such as deletions 5q 13q gain 6q were not observed There no failures therapy among 4-year event-free survival 100%. Overall, does exhibit unifying alterations but shows some suggesting that entity T-LLy.